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[] demonstrated significant improvement of melasma (mexametric analysis and improved MASI scores) when oral antioxidants were used as adjuncts, in comparison to placebo

Excluded from this analysis were clinical trials involving animals or healthy humans, nonrandomized trials, RCTs shorter than 12 weeks, retrospective studies, pooled analyses of clinical trials, conference proceedings, letters to editors, case reports, and articles that lacked relevant data on the outcomes of interest

GLP-1 acts through specific receptors found in the pancreas, gastrointestinal tract, and central nervous system to modulate insulin secretion, suppress glucagon, and slow gastric emptying

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