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2.3 Data extraction and risk of bias assessment Two independent reviewers (IR and SK) extracted the following data using a pre-tested form: Author name, publication year, country of origin

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Accordingly, the areas of unmet need for new treatments are reflected in the lesions that underly the hyperglycaemia, notably impaired function and number of pancreatic beta cells, insulin resistance and glucose toxicity, which are frequently aggravated by excess adiposity, abnormalities of glucagon secretion, an altered incretin response and disturbances in lipid metabolism [6]

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