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For comparison, the catalytic triad in enzymes like chymotrypsin, another well-known serine protease, comprises Histidine (His), Aspartic acid (Asp), and Serine (Ser)
[2] For epilepsy, topiramate should only be used in pregnancy if no suitable alternatives exist, with specialist oversight
This is even more likely in participants who are not achieving a satisfactory magnitude of weight loss
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