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This points to the hypothesis that chronic hyperglycemia in diabetes, along with dysregulated central sensing of glucose concentrations in diabetics, may impair central transport of GLP-1 receptor agonist and explain the reduced efficacy for weight loss in type two diabetic patients. Geisler also discussed astrocytes
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Mechanisms Before future studies are completed, it is worth entertaining how these results could be possible, given our current understanding of what GLP1R agonists can do
These therapies offer targeted action by stimulating insulin secretion only when blood glucose levels rise, reducing the likelihood of sudden drops in blood sugar
Gastroenterology &
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