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Much of the evidence rests on in-vitro fibroblast work, rodent wound-healing models, and small cosmetic-research panels

Cell death in cancer cell lines To evaluate the ability of leading candidate proteases to induce cell death via procaspase-1 and gasdermin D cleavage, we stably integrated X(PC) and X(GD), as well as catalytically inactive variants as negative controls, into cancer cell lines under doxycycline-induced expression (Fig

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the Epac-dependent signal induces explicitly expression of Mn-SOD, GPx-1, and catalase in cardiomyocytes and hepatocytes, reducing ROS and protecting cells from oxidative stress (43)