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These age restrictions reflect extensive clinical trials evaluating safety and efficacy across different developmental stages
Discontinuation rates improved from TRIUMPH-4 (18.2%) to TRIUMPH-1 (11.3%) to TRANSCEND-T2D-1 (5.1%)
In June 2025, the World Health Organization issued a medical product alert highlighting NAION as a potential risk associated with semaglutide-containing medicines (Ozempic, Wegovy, and Rybelsus)
So, it can only be from exogenous sources
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