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& ONeill, L

The peptide has several modifications that contribute to its extended half-life of five days [8]: an aminoisobutyric acid substitution at position 8 an arginine exchange at position 34 the incorporation of octadecanoic (C-18) diacid moiety at position 26 These refinements fortify its resilience against enzymatic degradation and augment its binding to serum proteins, facilitating a prolonged half-life and enabling once-weekly dosing [9]

Seventy to 80% of a dose exists as unchanged phentermine in urine when administered alone

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