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Hepatic in vitro metabolism of peptides

Although this technology was developed for highly efficient and precise manipulation of the Clostridioides difficile genome, the pyrE mutant constructed via ACE can serve as a universal host, applicable to mutagenesis studies in all Clostridia (including Clostridium acetobutylicum , Clostridium botulinum and others), which has been verified by genome resequencing to be free of additional mutations

Higher-risk patients require individualized planning

Oct 17: The FDA signed off on the first once-daily subcutaneous targeted C5 complement inhibitor for generalized myasthenia gravis (gMG) in the form of UCBs zilucoplan, now Zilbrysq

A new synthetic dual agonist of GPR120/GPR40 induces GLP-1 secretion and improves glucose homeostasis in mice