tirzepatide surmount-1 weight loss percent nejm 2022 Tirzepatide: In the trial, reduction percentages were dose-dependent: 5 mg: ~15.0% weight reduction. 10 mg: ~19.5% weight reduction. 15 mg: ~20.9% weight reduction (Jastreboff et al., 2022). https://www.nejm.org/doi/10.1056 📊 Semaglutide 2.4mg: −13.7% weight

It works by inhibiting melanin production: Glutathione interferes with the enzyme tyrosinase, which handles melanin synthesis, the pigment that gives skin its color

Targets stubborn bulges that resist diet and exercise

Though we may not yet have clear answers about the specific effects of GLP-1s on mental health, we know from the patients we share that the arrows connecting obesity and mental illness point in both directions

These symptoms occur because excess glutathione can increase glutamate levels (an excitatory neurotransmitter)

This approval signals a new era of personalized care for those living with the high-risk complications of IgAN