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Patients on warfarin need more frequent INR monitoring during GLP-1 initiation due to potential weight loss affecting vitamin K distribution and warfarin metabolism

By contrast, the Wegovy pill must be taken on an empty stomach with water, with no food, drink or other medicines for 30 minutes afterward - a factor doctors say has limited wider use of oral semaglutide for diabetes

While rare, more serious potential side effects include pancreatitis, gallbladder problems, kidney issues, allergic reactions and hypoglycemia (especially when used with other diabetes medications)

There are multiple agents in the class under development which should help increase competition and reduce cost, but they will remain expensive

Theres no expected interaction between semaglutide and topiramate