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Milk thistle is generally considered safe and well-tolerated for most adults
BPC-157 is described as well tolerated and without demonstrated toxicity in rodents, but the human safety dossier is unpublished, and over 80 percent of the literature comes from a single research group, so independent replication is limited Sikiric et al., 2025
The only other human study was in 2015
Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury
Results persist but gradually return toward baseline without ongoing support
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