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Lixisenatide inhibits neuroinflammation by promoting the proteasomal degradation of thioredoxin-interacting protein (TXNIP) in ocular tissues via the PI3K/Akt signaling pathway, an effect more potent than that of insulin
This allows metabolic processes to remain adaptive and responsive to contextsuch as nutrient availability, insulin sensitivity, and overall metabolic healthrather than being driven by constant stimulation (6)
Amino Acids
10.1016/j.biomaterials.2021.121110 91 OuyangP.HeX.YuanZ
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