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Clinical Note: These outcomes are based on trials involving FDA-approved semaglutide products
Mounjaro is approved to help manage type 2 diabetes while Zepbound is approved for weight loss in those with obesity or with overweight and at least one weight-related condition like high cholesterol
Mechanistically, SGLT2 inhibitors act predominantly through hemodynamic and cardiorenal pathways, whereas GLP-1 receptor agonists exert metabolic, anti-inflammatory, and anti-atherosclerotic effects, providing a rationale for potential complementarity
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