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Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as Doorstop for NADPH Entry
Del Prato S, Kahn SE, Pavo I et al (2021) Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial
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Introduction The presence of type 2 diabetes or maternal obesity during pregnancy increases the risk of adverse pregnancy outcomes and birth defects ( In a non-pregnant patient with type 2 diabetes, a GLP-1 agonist or SGLT2 inhibitor can be prescribed if adequate glycemic control is not achieved with metformin, sulphonylureas or (basal) insulin, or if weight reduction, hypoglycemia prevention or reduction of cardiovascular risk is the treatment goal ( Despite the fact that these novel glucose lowering medications have seen wide uptake in clinical practice, information regarding the safety of GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation is exceedingly scarce
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