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Nevertheless, kidney fibrosis is the end-stage renal disease (ESRD) and always be accompanied by the damage of ferroptosis-susceptible field, which is refered as iron metabolism, oxidative stress, inflammation, and autophagy [29,30,31]

Currently, researchers have identified several factors that may contribute to the etiology of depression, including biochemical, neuroendocrine, neuroimmunological, genetic, and psychosocial influences (Menard et al., 2016

The function of famous oncometabolites like 2-hydroxyglutarate, fumarate, or succinate has not been extensively described for the PC microenvironment

However, it is rarely used because of the high risk of patient injury during manipulation

Immune system: Lowers bacterial infection rates, restores immune cell functions, and eliminates certain bacteria (e.g., tuberculosis)