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Funder Information Declared Abbreviations T2D type 2 diabetes (T2D) HFD High-fat diet GLP-1 Glucagon-like peptide-1 GIP Glucose dependent insulinotropic polypeptide FOXO1 Forkhead box protein O1 PDX1 Pancreatic duodenum homeobox-1 MAFA MAF bZIP transcription factor A ALDH1A3 Aldehyde dehydrogenase 1A3 HOMA- Homeostasis model assessment of -cell function HOMA-IR Homeostasis model assessment of insulin resistance HbA1c Hemoglobin A1C

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