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Human-skin penetration research provides additional topical-delivery context [5]
The peptide backbone provides three coordination sites for copper: the free alpha-amino group of glycine, the deprotonated amide nitrogen of the glycyl-histidyl bond, and the imidazole nitrogen of the histidine side chain, with the lysine epsilon-amine remaining available for further interactions
However, in both models, cancer cell growth was rescued under cystine-free with GSH-supplemented conditions (Extended Data Fig
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