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The expression levels of TRINITY_DN25968_c1_g1 (glutamate-cysteine ligase catalytic subunit, GCLC ), TRINITY_DN4779_c0_g3 (glutathione reductase, GR ), TRINITY_DN17069_c0_g1, TRINITY_DN3645_c1_g1, TRINITY_DN47253_c0_g1 (glutathione S-transferase, GST ), TRINITY_DN7687_c0_g1 (5-oxoprolinase, 5-OPase ), and TRINITY_DN20556_c0_g1 (L-ascorbate peroxidase, APX ) were upregulated by 2.995.32-, 2.285.37-, 1.591.94-, 3.453.38-, 1.361.14-, 1.462.41-, 4.196.30-fold (log2), respectively, under Se supplementations, but TRINITY_DN72459_c0_g1 encoding glutathione peroxidase ( GPX ) was downregulated by 1.36- or 1.37-fold
This inhibition compromises the defense systems ability to counteract increased oxidative stress, leading to further damage to retinal cells
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