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Nicotine constricts blood vessels, reducing blood flow to the fracture site
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Rather than viewing receptor activation as a binary event, biased agonism allows selective amplification of therapeutically desirable signaling while minimizing pathways associated with adverse effects ( 3.2 From single-target optimization to rational polypharmacology Another major shift influencing the relevance of underexplored peptide systems is the growing acceptance of rational polypharmacology
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