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These observations highlight the need for large-scale, multicenter, randomized, placebo-controlled trials to ascertain whether targeted modulation of specific probiotic strains or other gut microbes associated with a lean phenotype can effectively counteract obesity and improve insulin sensitivity

The peptides versatility supports diverse scientific applications

It is marketed as a nasal spray (0.1% and 1% solutions) for the treatment of cognitive disorders, ischemic strokes, and optic nerve neuropathies

The DNA sequence spanning the CBS gene ARE motif located 4970 bp upstream of the transcript start site and its mutants were cloned into a GFP expressing reporter pEGFP-N1 (PT3054, Clontech) with sequence specific primers (Supplementary Table 1)

Lyophilized (freeze-dried) peptides are most stable when frozen for long-term storage