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While the Phase 2 trial did not specifically stratify outcomes by baseline eGFR, GLP-1 receptor agonists as a class have demonstrated renoprotective effects in at-risk populations

Diabetic Retinopathy Complications in Patients with a History of Diabetic Retinopathy: Rapid improvement of glucose control has been associated with temporary worsening of diabetic retinopathy

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Most patients start at a low dose and titrate upward over several weeks under physician guidance

Beyond treating type 2 diabetes and obesity, GLP-1 drugs are showing surprising, but not unwelcome, benefits for other health conditions