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Placebo-controlled trials similarly suggested higher effectiveness of tirzepatide, but study designs differed so results were not directly comparable, Rodriguez said
It is also worth noting that 'not working' can mean different things to different patients some may focus on weight changes, others on blood glucose readings, and some on symptom relief
LIR was also shown to cross the BBB following intraperitoneal administration at 25 and 250 nmol/kg, while no measurable increase in brain levels was detectable at the lowest tested dose, 30 min post-injection, nor at a later time point (3 h), even with the highest dose suggesting that LIRs brain penetration is both dose- and time-dependent (Hunter and Hlscher, 2012)
Abbreviations: T2DM, type 2 diabetes mellitus
