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For CVD health states, workforce non-participation was calculated by multiplying the workforce non-participation rate by the prevalence ratio of non-participation from a large Australian cross-sectional study (1.46 for MI, 1.92 for stroke and 1.83 for HF [36])

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115 In addition, liver insulin also effectively regulates lipid metabolism primarily by promoting cleavage and nuclear translocation of the sterol regulatory element binding protein 1c (SREBP-1c) 116,117 that activates lipogenesis in hepatocytes

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