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GCG signaling Unlike GLP-1 and GIP receptors, GCG show robust hepatic expression, enabling direct hepatic metabolic effects

The standard treatment ladder goes something like this: start with joint supplements (glucosamine, chondroitin), add omega-3 fatty acids, move to NSAIDs when things get bad, then consider surgery or prescription pain management

Generic protocols from the internet ignore most of that

In mouse liver, hepatocytes moderately express CD36 while the Kupffer cells are shown to strongly express CD36 (Yang et al., 2022)

Gradual dose escalation and patient education also contribute to better tolerance