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Variants in GLP1R , the direct target, and MC4R , a melanocortin receptor governing satiety, help describe the terrain the compound engages
The GLP-1 receptor is expressed in various tissues, but there is no evidence that its activation in reproductive tissues negatively affects sexual response
Research into the area is far from complete
The bioactive acylated form maintains its extended half-life, making it ideal for once-weekly dosing protocols in metabolic studies
Methods: Lipodystrophic insulin resistant and glucose intolerant seipin knockout mice were treated with the GLP-1R agonist liraglutide either acutely preceding analyses of insulin and glucose tolerance or chronically prior to metabolic phenotyping and ex vivo studies
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