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No detectable local or systemic toxicity was observed after repeated administration

GHK-Cu is widely used in cosmetics (recognized INCI, present in over 100 products)

Br J Clin Pharmacol 71:2028 Shayiq RM, Roberts DW, Rothstein K, Snawder JE, Benson W, Ma X, Black M (1999) Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury

tubulosa could inhibit D -galactosamine ( D -GalN)-induced hepatocyte death and also exhibited in vivo hepatoprotective effects at doses ranging from 25 to 100 mg/kg, po

Using a well-known blocker with potent antioxidant properties, a lowering of both HNE and 8OhdG adducts, alongside a decrease in total TTR deposits, has been noted [37]