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It adds that animal reproduction studies suggest potential risk while human data is absent, and that this uncertainty is what drives the conservative clinical recommendations that follow
He rated the product a 3 out of 5 for its instructions, and a 3 out of 5 for how easy it was to swallow
much of the rationale rests on shorter-term pharmacology and clinical experience
Therefore, we considered chow-fed C57BL/6 mice, which are non-pathological, to be sufficient controls since WD-fed MC4R-KO mice are a well-established MASH model that shows both steatosis and fibrosis 27
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