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The magnitude varies significantly between individuals: STEP 4 Trial : Participants who stopped semaglutide after 20 weeks regained approximately 7% body weight over next 48 weeks (compared to losing an additional 8% who continued medication) Real-World Studies : Variable outcomes

doi: 10.1038/nrendo.2012.140 115 DruckerDJBuseJBTaylorKKendallDMTrautmannMZhuangDet al

Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells

And the higher your dose, the more likely you are to experience it