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(2017c)
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doi: 10.1038/nrendo.2017.151 3 Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group
observed significantly elevated expression levels of inflammatory cytokines IL-4, IL-6, IL-17A, IL-21, IL-22, and TNF- in the vitreous cavity of patients with proliferative diabetic retinopathy (PDR) compared to the patients own serum concentrations and higher than the concentrations in the vitreous cavity of patients with epiretinal membranes or macular holes [151]
Each of these systems is compromised to varying degrees in T21 due to gene overexpression, oxidative stress, and immune dysregulation, making them ideal targets for metabolic restoration
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