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in this study, treatment with metformin improved glycemic control and reduced macrovascular complications (MI, stroke, peripheral vascular disease) in diabetic patients already on insulin therapy on a 4.3 years clinical follow-up (Kooy et al., 2009)

doi: 10.3389/fcell.2020.583850 Received 15 July 2020 Accepted 31 August 2020 Published 18 September 2020 Volume 8 - 2020 Edited by Vadivel Ganapathy, Texas Tech University Health Sciences Center, United States Reviewed by David Thwaites, Newcastle University, United Kingdom

Eating too late in the evening or consuming high-sugar foods close to bedtime can spike blood sugar and cortisol, both of which interfere with your ability to fall asleep and stay asleep

His concerns come from past findings with IGBs: Over time, they stop working

30 Liraglutide did not affect left ventricular function, but increased heart rate (mean difference 7 BPM