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Byrne, Giovanni Targher Liver International .2025;[Epub] CrossRef Discovery of Highly Potent, Selective, and Liver-Targeted THR- Agonists for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis Ju Liang, Yipei Gu, Liuyu Hu, Hui Qu, Nana Li, Chaoyue Xia, Lei Feng, Li Qin, Li Hai, Yaxi Yang, Ying Leng, Bing Zhou Journal of Medicinal Chemistry .2025
Products with REMS have narrower patient access by design
Preclinical research in rats and rabbits at doses up to 45 times the human therapeutic dose showed no malformations, miscarriage, or developmental delays
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