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Additional tests may include full blood count (to check for macrocytic anaemia), methylmalonic acid and homocysteine levels (which rise in B12 deficiency), and tests for intrinsic factor antibodies if pernicious anaemia is suspected

No clear evidence defines the ideal level within the normal range

Similarly, evidence concerning potential drugpeptide interactions is largely unavailable

Definition [edit] Vitamin B 12 is a coordination complex of cobalt, which occupies the center of a corrin ligand and is further bound to a benzimidazole ligand and adenosyl group

However, high dose oral vitamin B12 therapy can also be effective, provided that the dose is sufficient, medication adherence is good, and a response is documented