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Additionally, the generation of hydrogen peroxide by the FLCs further intensifies the renal injury, stimulating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and apoptosis signal-regulating kinase 1 (ASK1), as well as the Janus kinases(JAK) and signal transducer and activator of transcription proteins (STATs) pathway [78]

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