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10.1152/ajpgi.1997.273.1.G7 Am J Physiol Gastrointest Liver Physiol

Substrate promiscuity and hyperoxidation susceptibility as potential driving forces for the co-evolution of Prx5-Type and Prx6-Type 1-Cys peroxiredoxin mechanisms

A candidate for a potential glutathione-scaffold residue was identified using the following selection criteria: The residue should be rather conserved in enzymatically active in contrast to inactive glutaredoxins and have a charged side chain to ensure a strong ionic glutathione interaction (Fig

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