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One way in which Htt aggregates could cause toxicity is through depleting ubiquitin, a protein that binds to misfolded proteins to promote their clearance through the ubiquitin-proteasome system ( Notably, the N-terminal 17-residue domain stretch of huntingtin folds into an amphipathic -helix in the presence of membranes (Pandey et al., 2018)

Maintenance dose is given as per need

For others, it is debilitating nausea, vomiting, diarrhea, or severe constipation that makes daily life impossible

It is a synthetic peptide - a short chain of 15 amino acids - that was originally derived from a protein found in human gastric juice

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