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instead, it promotes the efficient utilization of existing fat stores as a fuel source

For patients with pre-existing diarrhea or fat malabsorption after cholecystectomy, slower titration schedules may improve adherence

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A BMI of 30 or more, at least in the western population, is obesity

It demonstrated that GLP-1 receptor agonists significantly increase the risk of gastrointestinal adverse events, with nausea being the most frequently reported outcome, and substantial heterogeneity across agents, particularly for orforglipron, exenatide, tirzepatide, semaglutide, and liraglutide