glp 1 hormone activator Body-wide multi-omic counteraction of aging with GLP-1R agonism: Cell Metabolism triple action glp 1 acting

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N Engl J Med 377(12):11191131

This is not really that baffling, another comment explained this phenomenon, and from what I can tell his background is in Law, yet he got the feedback loop involved in GLP1as and possible contraindications with T2D

This decline is a direct result of the entrance of more effective agents including Wegovy (semaglutide), approved in 2021, and Zepbound (tirzepatide), approved in 2023

Notably, atheroprotective LS activates KLF2 expression in ECs, whereas disturbed flow or OS reduces its expression through upregulating miR-92a [202]