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[6] Because NAD + -dependent enzymes are involved in DNA repair, protein deacetylation, stress responses, mitochondrial function, and cellular signaling, NNMT-related changes in NAD + availability should be interpreted in a pathway-specific manner rather than as a simple beneficial-or-harmful binary
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I would like to refer you to a rheumatologist to get their opinion on this at University of Iowa if you are okay with this
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