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In experimental SCI models, edaravonea free radical scavengerupregulates GPX4 and xCT while reducing ACSL4 and ROS levels, indicating its capacity to ameliorate acute ferroptosis in SCI (246)
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By contrast, late intervention likely impedes the recruitment of reparative Ly6C low macrophages and expression of proangiogenic factors, ultimately suppressing neovascularization and tissue repair
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