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ALL cells themselves can alter the endosteal and vascular compartments of the niche12 and induce apoptosis of osteoblast cells.17 The remodelled niche is dynamically transient and on exposure to chemotherapeutic agents, ALL cells can release CCL3 and cytokines TGF-1 and GDF15, conferring chemoresistance by activating the TGF- signaling pathway.12 It may be possible to overcome this resistance by disrupting the interactions between leukemia cells and the BM environment
Minimizing and managing side effects Proactive strategies reduce the likelihood of side effects and help manage any that occur
doi: 10.1155/2024/6645155 256 KimSOChoiALeeHHLeeJYParkSJKimBH
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Retinoids can increase skin sensitivity, and vitamin C is acidic enough to compromise the stability of copper peptides if used together
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