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Thus, in mice, significant antihyperglycaemic effects of DPP-4 inhibition are still apparent in animals lacking the GLP-1 receptor (43), while in clinical studies, GLP-1 receptor antagonism (using exendin 9-39) eliminates only approximately half of the glucose-lowering effect in patients with T2DM treated with DPP-4 inhibitors (44, 45)
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High Blood Pressure Weight-loss medications can cause an abnormal increase in blood pressure, as these drugs may interfere with proper blood circulation, leading to insufficient blood flow to vital organs
Reason #3: Rapid weight loss can temporarily disrupt fertility When youre losing weight quicklyespecially 2+ pounds per weekyour hormones undergo significant shifts
Weight loss during GLP-1 treatment can change levothyroxine dose needs, even when the medications themselves are otherwise tolerated together
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