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Each peptide belongs to the class of Growth Hormone Secretagogues (GHS), with overlapping but distinct mechanisms that may collectively enhance Growth Hormone (GH) release, Insulin-Like Growth Factor 1 (IGF-1) expression, and downstream anabolic processes
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On the other hand, the appetite-suppressing effects of chronic systemic exendin-4 are preserved in mice lacking GLP-1Rs in ARC POMC neurons [128] or when ARC neurons are ablated [34]
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