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In contrast, the EFSA reports that a cut-off value of 750 nmol/l is used for the diagnosis of cobalamin deficiency for all ages (EFSA, 2015)

While anecdotal reports and some preliminary research suggest that it may aid in weight reduction by promoting gut health and improving metabolic function, there is currently insufficient scientific evidence to validate these claims fully

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), not a peptide

This is observed as well in our series of patients, as Supplementary Table 1 demonstrates, although we have not been able to objectively show muscle weakness in our cohort