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Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity
Specialized tests exist in some research or advanced laboratory settings, but they are not commonly needed to answer the question of whether someone is healthy
Caution is advised in patients with Leber optic atrophy, a genetic disorder caused by chronic cyanide intoxication (such as from smoking, alcohol or some plants), against the use of cyano-B12 due to its cyanide moiety, whilst hydroxo-B12 is a cyanide antagonist and can therefore be used in these patients
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For instance, atovaquone, a known antimalarial, acts by inhibiting parasite mitochondrial cytochrome bc1 complex, demonstrating the feasibility of mitochondria-focused antiparasitic strategies (Sheokand et al., 2024)
