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That single human study
Pros and Cons: A Balanced Risk Assessment Potential 'Pros' (Theoretically Claimed): No UV exposure required (though unsafe alternative) Perceived convenience over topical applications Documented Cons: Severe nausea/vomiting (70-80% of users) 10 Unpredictable skin darkening (patchy results, permanent freckling) Increased mole count and darkening (melanoma risk factor) 11 Zero quality control (contamination risks with bacteria/endotoxins) Legal consequences (classified as unapproved drugs in US/EU) When it might be 'suitable': Never for cosmetic use
IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migration
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