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It's not just about the numbers, though
50,51 Elafibranor was tested in the phase 2b GOLDEN-505 trial (NCT01694849) which randomized 276 patients with NASH without cirrhosis to elafibranor 80 mg, elafibranor 120 mg or placebo groups in a 1:1:1 fashion (Table 3)
In fact, around 50% of adults taking GLP-1 medications struggle to afford them , emphasizing the urgent need for more accessible options
For once-daily GLP-1 medications like liraglutide (Victoza, Saxenda), there is similarly no absolute requirement to inject at a specific time
The math changes as you get smaller, and forcing an aggressive deficit at a lower weight is a recipe for muscle loss and metabolic adaptation
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