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It is highly recommended to consult with a qualified healthcare professional before making any decisions regarding medication, treatment, or healthcare management

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

For the full triple-agonist effect including glucagon-driven fat oxidation, doses of 4mg weekly or higher appear necessary

This is concerning because loss of skeletal muscle can lead to decreased strength, reduced functional capacity, and a lower resting metabolic rate, potentially making weight regain more likely after medication discontinuation