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Once T3 binds to TRs, it activates or represses the transcription of many genes
The lack of central carbon and nitrogen catabolism not only leads to energy deficiency but also reduces the supply of the main metabolite anabolic precursors such as pyruvate, acetyl-CoA, glucose-6-phosphate, and erythrose 4-phosphate used for biomass biosynthesis 21
Recovery after hyperthermic treatment
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A 2023 European Food Safety Authority opinion set an even lower adult limit of 255 mcg a day
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