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Furthermore, GLP-1 receptor agonists have neuroprotective effects in the hippocampus, including enhanced neurogenesis and reduced apoptosis in studies primarily conducted in adult males (32,3841)
While selective GLP-1 treatment (e.g., Semaglutide 1 mg) resulted in a mean HbA1c reduction of approximately 1.86%, pretreatment and escalation with Tirzepatide at 5, 10, and 15 mg doses significantly increased these reductions to 2.01%, 2.24%, and 2.30%, respectively
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