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In individuals with PCOS , insulin resistance and excess weight can interfere with ovulation , making it difficult to conceive
GLP-1 receptor agonists, such as Semaglutide and Ozempic, mimic the action of this hormone, leading to improved blood sugar control and other metabolic benefits
The Bottom Line GLP-1 receptor agonists are among the most effective weight loss medications ever developed
However, in A Diabetes Outcome Progression Trial (ADOPT), metformin exhibited a reduced risk of monotherapy failure compared with the sulfonylurea glibenclamide (known as glyburide in the USA and Canada) and slower rate of loss of beta cell function, although it was inferior to the thiazolidinedione rosiglitazone [20]
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